The role of skin microbiota in lichen planus from a Mendelian randomization perspective

Lichen planus is a chronic skin lesion characterized by pruritic violaceous papules, which has a high risk of morbidity. Skin microbiota plays an important role in the maintenance of cutaneous mucosal barrier and human health and immune homeostasis. Studies have shown that skin microbiota may play a role in the pathogenesis of lichen planus, but it is not yet clear. MR studies have been performed to determine causal associations. Lichen planus samples from Finn database were extracted from published GWAS data, including 6,411 cases and 405,770 controls; skin microbiota samples were gathered from a meta-analysis of German population-based GWAS, which included 1,656 skin samples from two cohorts: KORA FF4 (n = 353) and PopGen (n = 294), comprising 4,685,714 SNPs. The IVW method was used as the main statistical method, supplemented by three methods: MR-Egger, weighted median and weighted mode. FDR correction and MR Steiger test were used to reduce false positives. IVW method revealed a negative correlation between Burkholderia in the moist anterior elbow and lichen planus (OR: 0.934, 95% CI: 0.910-0.986, P = 0.017). These associations remained stable following false discovery rate correction (P < 1e-5). Our study highlights a possible causal role of Burkholderia in the development of lichen planus and suggests that Burkholderia may reduce the occurrence of lichen planus by affecting macrophages.