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Association of IL6 Gene Polymorphisms and Neurological Disorders: Insights from Integrated Bioinformatics and
Md Harun-Or-Roshid1, Md Nurul Haque Mollah1, Jesmin2
1Department of Statistics, University of Rajshahi, Rajshahi, Bangladesh.
Neuromolecular Medicine
|January 15, 2025
Summary
Interleukin 6 (IL6) gene variants are linked to neurological disorders and brain cancer. Specific IL6 SNPs show significant associations with conditions like Alzheimer's, Parkinson's, and glioma, suggesting their potential as biomarkers.
Area of Science:
- Genetics
- Neuroscience
- Oncology
Background:
- Interleukin 6 (IL6) is a key inflammatory biomarker implicated in central and peripheral nervous system diseases.
- Genetic variations in the IL6 gene may influence susceptibility and progression of neurological disorders (NDs) and brain cancers.
Purpose of the Study:
- To investigate the association between specific Interleukin 6 (IL6) gene variants (rs1800795, rs1800796, rs1800797) and the risk of neurological disorders and brain cancer.
- To explore the potential role of IL6 in brain cancer development and prognosis using bioinformatics analyses.
Main Methods:
- A comprehensive meta-analysis of case-control studies was performed on IL6 single nucleotide polymorphisms (SNPs) and neurological disorders.
- Bioinformatics tools (GTEx, TCGA) were utilized to analyze IL6 expression, copy number alterations, and their correlation with brain cancer characteristics.
- Disease-stratified and ethnicity-stratified analyses were conducted to identify specific associations.
Main Results:
- Significant correlations were found between IL6 SNPs (rs1800795, rs1800796) and overall neurological disorders.
- rs1800795 showed associations with Schizophrenia, Alzheimer's, and Parkinson's diseases, while rs1800796 was linked to Celiac disease.
- IL6 SNPs (rs1800795, rs1800797) were significantly associated with Glioma. Increased IL6 expression correlated with cancer severity, hypoxia, and reduced survival in brain cancer patients.
Conclusions:
- Specific IL6 gene variants are significantly associated with an increased risk of various neurological disorders.
- IL6 plays a role in brain cancer development and progression, with elevated expression linked to poorer patient outcomes.
- IL6 SNPs represent potential prognostic biomarkers for neurological conditions and brain cancer.
