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Related Experiment Video

Updated: Jun 2, 2025

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

Late-onset Systemic Lupus Erythematosus.

Prakashini Mruthyunjaya¹, Sakir Ahmed², Aliya Botabekova^3,4

¹Department of Clinical Immunology and Rheumatology, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, 751024, India. m.v.prakashini@gmail.com.

Rheumatology International

|January 15, 2025

Summary

This summary is machine-generated.

Late-onset systemic lupus erythematosus (SLE), diagnosed after age 50, presents unique challenges including diagnostic delays and multimorbidity. Optimizing treatment for older adults with SLE is crucial for better outcomes.

Keywords:

Geriatrics Immune senescence Late onset disorders Multimorbidity Systemic lupus erythematosu

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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Area of Science:

Rheumatology
Immunology
Geriatrics

Background:

Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting multiple organ systems.
Late-onset SLE (Lo-SLE), diagnosed after 50-65 years, accounts for nearly 20% of cases.
Lo-SLE exhibits distinct characteristics, including a reduced female predominance and higher rates of damage accrual.

Purpose of the Study:

To highlight the unique aspects of late-onset SLE (Lo-SLE).
To emphasize the importance of timely diagnosis and tailored treatment strategies for Lo-SLE.
To underscore the impact of multimorbidity in older adults with SLE.

Main Methods:

Review of existing literature on late-onset SLE.
Analysis of demographic and clinical differences between Lo-SLE and early-onset SLE.
Discussion of challenges in diagnosis and management of Lo-SLE.

Main Results:

Lo-SLE often presents atypically, leading to diagnostic delays.
Patients with Lo-SLE experience significant multimorbidity, including osteoporosis, sarcopenia, and cardiovascular issues.
Damage accrual is higher in Lo-SLE, potentially due to delayed diagnosis and treatment.

Conclusions:

Increased awareness and earlier diagnosis of Lo-SLE are essential.
Treatment plans must consider age-related factors, comorbidities, and minimize long-term steroid exposure.
Integrating non-pharmacological interventions can improve quality of life for Lo-SLE patients.