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Development of biomaterials for bone tissue engineering based on bile acids.
Yongjun Liu1, Xiaojie Liu2, Chang Liu2
1The Second Department of Spine Surgery, Yantaishan Hospital, Yantai, People's Republic of China.
Journal of Materials Science. Materials in Medicine
|January 15, 2025
Summary
Bile acids (BAs) show promise for bone regeneration, offering antioxidant and anti-inflammatory benefits. This review explores their role in bone healing and applications in biomaterials for bone reconstruction.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Biochemistry
Background:
- Bone loss from disease/injury impacts quality of life and incurs high costs.
- Bone tissue engineering (BTE) offers an alternative to transplantation due to donor limitations.
- Biomaterials are crucial for BTE, requiring consideration of osteogenesis, bone conduction, and induction.
Purpose of the Study:
- To review the role and mechanisms of bile acids (BAs) in bone healing.
- To highlight the unique properties of BAs for bone regeneration.
- To discuss applications of BAs in biomaterials for bone reconstruction.
Main Methods:
- Literature review focusing on bile acids in bone healing.
- Analysis of BA properties: antioxidant, anti-inflammatory, immunosuppressive.
- Examination of BA applications in gel fabrication, microencapsulation, and nanotechnology.
Main Results:
- Bile acids possess significant antioxidant, anti-inflammatory, and immunosuppressive properties.
- BAs effectively promote bone and tissue regeneration.
- Combining BAs with other materials can enhance local bone regeneration and control release.
Conclusions:
- Bile acids are a promising strategy for bone regeneration.
- BA-derived biomaterials offer potential for bone reconstruction.
- Further advancements in BA applications are expected for improved bone healing outcomes.
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