JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

Efficacy and safety of preoperative duloxetine in reducing post-laparoscopic surgery pain: a meta-analysis of randomized placebo-controlled trials

  • 0Department of Medicine, Evangelical University of Goiás, Avenida Universitária Km 3.5, Cidade Universitária, Anápolis, GO, 75083-515, Brazil. eduardo.cerchi27@gmail.com.
International Journal of Clinical Pharmacy +

|

January 15, 2025

|

January 15, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Preoperative duloxetine significantly reduces postoperative pain and the need for analgesics in laparoscopic surgery patients. This treatment also lowers the risk of nausea and vomiting, improving patient recovery.

Area Of Science

  • Anesthesiology and Pain Management
  • Pharmacology
  • Surgical Outcomes

Background

  • Emerging evidence suggests duloxetine may mitigate postoperative pain and analgesic needs post-surgery.
  • The safety profile of duloxetine in this perioperative context requires further investigation.

Purpose Of The Study

  • To systematically review and meta-analyze randomized controlled trials (RCTs) evaluating preoperative duloxetine versus placebo for postoperative pain management.
  • To assess the efficacy and safety of duloxetine in adults undergoing laparoscopic surgery.

Main Methods

  • A comprehensive search of MEDLINE, Embase, and Cochrane Library databases was conducted.
  • Four RCTs involving 227 patients were included in the meta-analysis.
  • Random-effects models were employed to determine mean differences and risk ratios for various outcomes.

Main Results

  • Duloxetine significantly reduced pain scores at 2, 4, 8, 12, and 24 hours post-surgery compared to placebo.
  • Patients receiving duloxetine experienced a statistically significant delay in the time to first analgesic requirement.
  • A reduced risk of nausea and vomiting was observed in the duloxetine group, with no significant differences in dizziness, headache, or somnolence.

Conclusions

  • Preoperative duloxetine is effective in minimizing postoperative pain intensity following laparoscopic surgery.
  • Duloxetine administration delays the need for rescue analgesia and reduces the incidence of postoperative nausea and vomiting.
  • The findings support the use of duloxetine as a perioperative adjunct for pain management in laparoscopic procedures.

Keywords: