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Updated: Jun 2, 2025

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS
Published on: March 14, 2013
Metabolic Profiling: A Perspective on the Current Status, Challenges, and Future Directions.
Helen G Gika1,2, Georgios Theodoridis2,3,4, Ian D Wilson5
1Department of Medicine, Aristotle University, Thessaloniki, Greece.
Metabolic phenotyping, also known as metabolomics, is a globally researched field. This perspective reviews its current status, challenges, and future directions in biomarker and systems biology research.
Area of Science:
- Biomarker Research
- Systems Biology
- Metabolomics
Background:
- Metabolic profiling is a rapidly advancing scientific field.
- Research is conducted globally across various laboratory scales.
- It plays a crucial role in understanding biological systems.
Purpose of the Study:
- To provide a perspective on the current status of metabolic phenotyping.
- To identify key challenges in the field of metabolomics.
- To consider future research directions for metabolic profiling.
Main Methods:
- Literature review and expert perspective.
- Analysis of global research trends in metabolic phenotyping.
- Discussion of current technological and analytical challenges.
Main Results:
- Metabolic phenotyping is a widespread and growing area of research.
- Significant challenges exist in data analysis, standardization, and interpretation.
- The field holds immense potential for biomarker discovery and systems biology.
Conclusions:
- Metabolic phenotyping is a vital and evolving discipline.
- Addressing current challenges is crucial for future advancements.
- Continued research will enhance its application in health and disease.
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