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Blood Transfusion and Agglutination

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

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Related Experiment Video

Updated: Jun 2, 2025

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt

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INTERNATIONAL NORMALIZED RATIO AND ACTIVATED PARTIAL THROMBOPLASTIN TIME DO NOT PREDICT PLASMA TRANSFUSION IN LIVER

David Silveira Marinho¹, Joel Avancini Rocha Filho², Estela Regina Ramos Figueira³

¹Department of Anesthesiology, Faculty of Medicine, Universidade Federal do Ceará - Fortaleza (CE), Brazil.

Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery

|January 15, 2025

Summary

International Normalized Ratio (INR) and activated partial thromboplastin time (aPTT) poorly predict fresh frozen plasma transfusions during liver transplantation (LT). Preoperative hematocrit, fibrinogen, and absence of hepatocellular carcinoma are better indicators for transfusion needs.

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Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

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Published on: November 7, 2020

Area of Science:

Hepatobiliary Surgery
Transplantation Medicine
Hematology

Background:

Liver transplantation (LT) is associated with significant blood loss, impacting patient and graft survival.
Accurate monitoring of hemostasis is crucial for managing bleeding complications in LT.
Traditional coagulation tests like INR and aPTT have questionable accuracy in cirrhotic patients.

Purpose of the Study:

To evaluate the utility of INR and aPTT in guiding fresh frozen plasma transfusions during LT.
To identify predictors of plasma transfusion requirements in LT recipients.

Main Methods:

Retrospective cohort study of 297 cirrhotic patients undergoing LT.
Measurement of INR and aPTT across different surgical phases.
Analysis of intraoperative plasma transfusion data and patient characteristics.

Main Results:

INR and aPTT showed low accuracy in predicting plasma transfusions.
Preoperative hematocrit, preoperative fibrinogen, and absence of hepatocellular carcinoma were significant predictors of plasma transfusion.

Conclusions:

Standard coagulation tests (INR, aPTT) are insufficient for guiding plasma transfusions in LT.
A more comprehensive strategy is needed for effective hemostatic management in LT to improve outcomes.