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Optimizing etodolac and quercetin loaded MSNs using taguchi design: an approach for enhancing drug loading efficiency
Sourav Chougule1, Hafiz Ahmed1, Snigdha Singh1
1NanoTech Laboratory, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) Guwahati, Changsari, Kamrup 781101, Assam, India.
Journal of Pharmaceutical Sciences
|January 15, 2025
Summary
Mesoporous silica nanoparticles (MSN) offer high drug loading efficiency for etodolac and quercetin. Optimizing solvent and process parameters is crucial, as generalized drug loading procedures for MSNs are ineffective.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Mesoporous silica nanoparticles (MSN) are promising drug carriers due to high drug loading capacity.
- Drug loading into MSNs presents challenges compared to lipid-based systems.
- Tailoring synthesis and loading parameters is essential for efficient drug delivery.
Purpose of the Study:
- To investigate and optimize the drug loading of etodolac (ETD) and quercetin (QUR) into MSNs.
- To evaluate the impact of various process parameters on drug loading efficiency.
- To assess the effect of MSN loading on drug solubility and in vitro release.
Main Methods:
- MSNs were synthesized and characterized using BET analysis (Type IV isotherm).
- Taguchi Design of Experiments (DOE) was employed to study parameters like solvent, drug-MSN ratio, loading time, and stirring speed.
- In vitro drug release studies and kinetic modeling were performed.
Main Results:
- High drug loading efficiencies were achieved (19.04% for ETD, 11.40% for QUR).
- Solvent selection significantly impacted ETD loading but not QUR loading, indicating no universal loading protocol.
- Drug loading into MSNs enhanced aqueous solubility by 3.08-fold for ETD and 2.5-fold for QUR.
Conclusions:
- Optimized MSN formulations significantly improve drug solubility and loading.
- Process parameter optimization, particularly solvent selection, is critical and drug-specific for MSN drug loading.
- Further investigation into in vitro release mechanisms is necessary for comprehensive drug delivery evaluation.
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