A review of recent progress in alginate-based nanocomposite materials for tissue engineering applications

Integrating nanotechnology with tissue engineering has revolutionized biomedical sciences, enabling the development of advanced therapeutic strategies. Tissue engineering applications widely utilize alginate due to its biocompatibility, mild gelation conditions, and ease of modification. Combining different nanomaterials with alginate matrices enhances the resulting nanocomposites' physicochemical properties, such as mechanical, electrical, and biological properties, as well as their surface area-to-volume ratio, offering significant potential for tissue engineering applications. This review thoroughly overviews various nanomaterials, such as metal and metal oxide nanoparticles, carbon-based nanomaterials, MXenes, and hydroxyapatite, that modify alginate-based nanocomposites. It covers multiple preparation techniques, including layer-by-layer assembly, blending, 3D printing, and in situ synthesis. These techniques apply to tissue engineering applications, including bone tissue engineering, cardiac tissue engineering, neural tissue engineering, wound healing, and skin regeneration. Additionally, it highlights current advancements, challenges, and future perspectives.