Related Experiment Video
Updated: Jun 2, 2025
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
Life-threating Asthma Exacerbation Successfully Treated with Benralizumab
Suzuka Matsuoka1, Kenichiro Kudo1, Mayu Goda1
1Department of Respiratory Medicine, NHO Okayama Medical Center, Japan.
Abstract:
A 52-year-old Japanese man with a history of childhood asthma presented at our emergency department with progressive dyspnea. Despite subcutaneous adrenaline injections, salbutamol nebulization, and intravenous methylprednisolone, the carbon dioxide partial pressure (pCO2) increased to 110 mmHg. The patient was intubated, and mechanical ventilation was initiated because of severe respiratory failure. Severe bronchospasm frequently occurs despite appropriate treatment. Therefore, we decided to administer biologics. After the administration of a single dose of benralizumab, his respiratory condition improved, with normalization of pCO2, tidal volume, and airway resistance. We successfully extubated the patient two days after the administration of benralizumab.
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