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Extensive but Steroid-sensitive Pulmonary Infiltration by Natural Killer-large Granular Lymphocytic Leukemia
Masahiro Tokunaga1, Satoshi Tetsumoto2, Hayato Maruoka3
1Department of Hematology, Suita Municipal Hospital, Japan.
Internal Medicine (Tokyo, Japan)
|January 15, 2025
Summary
This study reports the first case of pulmonary infiltration in a patient with natural killer (NK) large granular lymphocytic leukemia (NK-LGLL). Treatment with prednisolone alone effectively reduced lung lesions.
Area of Science:
- Hematology
- Pulmonology
- Oncology
Background:
- Natural Killer (NK) large granular lymphocytic leukemia (NK-LGLL) is a rare lymphoproliferative disorder.
- Pulmonary involvement in NK-LGLL is uncommon and presents diagnostic challenges.
Purpose of the Study:
- To describe a case of pulmonary infiltration secondary to NK-LGLL.
- To report the efficacy of prednisolone monotherapy in managing pulmonary lesions in NK-LGLL.
Main Methods:
- Diagnosis of pulmonary infiltration was confirmed via computed tomography, bronchoalveolar lavage flow cytometry, and thoracoscopic lung biopsy.
- Treatment involved oral prednisolone at 1 mg/kg.
Main Results:
- The patient presented with persistent NK cell proliferation and infiltrative pulmonary lesions.
- Flow cytometry and histology confirmed NK-LGLL infiltration of the lungs.
- Prednisolone treatment led to a durable reduction in pulmonary lesions.
Conclusions:
- Pulmonary infiltration is a potential manifestation of NK-LGLL.
- Prednisolone monotherapy can be an effective treatment for pulmonary NK-LGLL.
- This case highlights the importance of considering NK-LGLL in patients with unexplained pulmonary infiltrates.
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