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Related Concept Videos

Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

141
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
141

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Related Experiment Video

Updated: Jun 2, 2025

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
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Software Discrepancies in Radionuclide-Derived Left Ventricular Ejection Fraction.

Rune H Kappel1,2,3,4, Helle Precht3,5,6,7,8, Thomas Q Christensen7,9

  • 1Faculty of Health Science, University of Southern Denmark, Odense, Denmark; runekappel96@live.dk.

Journal of Nuclear Medicine Technology
|January 15, 2025
PubMed
Summary
This summary is machine-generated.

Different software packages for gated equilibrium radionuclide angiography (ERNA) show significant variability in calculating left ventricular ejection fraction (LVEF). These ERNA software programs are not interchangeable, necessitating caution when switching analysis tools.

Keywords:
CMRERNA/MUGALVEFinter-/intrareadersoftware

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Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Medical Imaging Analysis

Background:

  • Gated equilibrium radionuclide angiography (ERNA) is crucial for monitoring left ventricular ejection fraction (LVEF) in patients undergoing cardiotoxic chemotherapy.
  • Low inter- and intrareader variability is essential for accurate LVEF assessment to detect true changes.

Purpose of the Study:

  • To investigate inter- and intrareader variability in LVEF measurements using two commercial software packages.
  • To compare ERNA software variability against cardiac MRI (CMR) as a reference standard.

Main Methods:

  • 46 ERNA scans were analyzed for LVEF using Xeleris and Corridor4DM software by two technologists.
  • Cardiac MRI (CMR) was performed within 1.5 hours as a reference standard.
  • Bland-Altman analysis and Lin concordance correlation coefficient (CCC) assessed agreement and bias.

Main Results:

  • Corridor4DM yielded significantly higher mean LVEF than Xeleris.
  • No significant interreader variability was found within the same software.
  • Both software packages demonstrated significant bias compared to CMR, with Xeleris showing less bias (4%) than Corridor4DM (11%).
  • Xeleris showed higher correlation with CMR (CCC 0.438/0.572) compared to Corridor4DM (CCC 0.257/0.244).

Conclusions:

  • A high degree of variability exists between different software packages for ERNA LVEF calculation.
  • ERNA software programs for LVEF assessment are not interchangeable.
  • Caution is advised when switching between ERNA software packages for patient monitoring.