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Updated: Jun 2, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Physical function, functional capacity, cognition, and brain structure and function in older adults with chronic
Mary F Hannan1, Olu Ajilore2, Xiaohong Joe Zhou3
1College of Nursing, University of Illinois Chicago, Chicago, IL, USA.
Objective:
To evaluate associations between brain structure/function with physical function and functional capacity in older adults with CKD and cognitive complaints.
Methods:
We evaluated associations between neuroimaging and cognitive function with functional capacity and physical function in older adults (60-80years) with CKD and cognitive complaints (n = 39; age 67.6 years).
Results:
In multivariable analysis, each standard deviation (SD) increase in 6-minute walk test (6MWT) distance (functional capacity) was associated with better attention/information processing (Trails Making Test-A (TMT-A) (ß -10.86, 95% Confidence Interval (CI) -16.67, -5.06); digit symbol test (ß 5.24, 95% CI 1.02, 9.46)), and each SD increase in short physical performance battery (SPPB)(physical function) was associated with better attention/information processing (TMT-A) (ß -10.99, 95% CI -16.59, -5.39). 6MWT distance and SPPB were associated with some indicators of brain structure/diffusivity.
Conclusion:
In older adults with CKD and cognitive complaints, functional capacity and physical function may be associated with cognition and brain structure/function.
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