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Updated: Jul 7, 2026

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging
06:08

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Published on: February 7, 2014

Accuracy of pulse wave velocity for screening coronary artery disease: a systematic review and meta-analysis

Carla-Geovanna Lever-Megina1, Iván Cavero-Redondo1, Celia Álvarez-Bueno2

  • 1CarVasCare Research Group, Facultad de Enfermería de Cuenca, 16733 Universidad de Castilla-La Mancha , Cuenca, Spain.

Diagnosis (Berlin, Germany)
|January 15, 2025
PubMed

Insights

Pulse wave velocity (PWV) shows promise as a noninvasive method for detecting coronary artery disease (CAD). This systematic review suggests PWV can effectively screen for CAD, potentially improving patient outcomes and healthcare efficiency.

Area of Science:

  • Cardiology
  • Diagnostic Accuracy
  • Medical Imaging

Background:

  • Coronary artery disease (CAD) is a major cause of cardiovascular events, with high prevalence and healthcare costs.
  • Current CAD screening methods are invasive and expensive, necessitating alternative approaches.
  • Noninvasive techniques are crucial for early detection and prevention of cardiovascular events.

Purpose of the Study:

  • To evaluate the diagnostic accuracy of pulse wave velocity (PWV) for detecting coronary artery disease (CAD) in patients with suspected CAD.
  • To compare the efficacy of PWV against the gold standard diagnostic method, angiography.
  • To determine the potential of PWV as a noninvasive screening tool for CAD.

Main Methods:

  • A systematic review and meta-analysis of studies comparing PWV and angiography for CAD detection.
  • Literature search conducted in PubMed, Scopus, and Web of Science databases up to August 2024.
  • Quality assessment using QUADAS-2 tool and publication bias assessment using Deeks' method.

Main Results:

  • Eight cross-sectional studies were included, measuring CAD simultaneously by PWV and angiography.
  • The diagnostic odds ratio (dOR) for PWV in detecting CAD was 3.61.
  • This dOR indicates a significant ability of PWV to identify the presence or absence of CAD.

Conclusions:

  • Pulse wave velocity (PWV) demonstrates a high probability of detecting coronary artery disease (CAD).
  • Implementing PWV as a screening technique could benefit patients with suspected CAD.
  • PWV offers a potential for increased efficiency in healthcare resource utilization for CAD screening.

Keywords:
angiographycoronary artery diseasediagnostic accuracy studiesmeta-analysispulse wave velocityscreening

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