Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Laparoscopic transabdominal approach for radical excision of low-lying presacral cyst: a case report and narrative mini-review.

Frontiers in oncology·2026
Same author

Integrated model based on ultrasound attenuation and metabolic biomarkers for noninvasive assessment of hepatic fat fraction categories in MASLD: a QCT-referenced study.

Frontiers in physiology·2026
Same author

Correction: Advances in quantitative ultrasound for metabolic dysfunction-associated steatotic liver disease diagnosis.

Frontiers in physiology·2026
Same author

Advances in quantitative ultrasound for metabolic dysfunction-associated steatotic liver disease diagnosis.

Frontiers in physiology·2026
Same author

Cholesterol transfer proteins promote Atg-independent ER clearance by lysosomes.

Cell reports·2026
Same author

Dynamic network analysis of air pollution-related health vulnerability: Implications for policy synergy.

Environmental pollution (Barking, Essex : 1987)·2026

Related Experiment Video

Updated: Jun 2, 2025

Author Spotlight: Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos
12:35

Author Spotlight: Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos

Published on: April 14, 2023

1.3K

Chemo-optogenetic Dimerization Dissects Complex Biological Processes.

Donglian Wu1,2, Xiaofeng Sun1,2, Xi Chen1,2

  • 1Laboratory of Chemical Biology and Frontier Biotechnologies, The HIT Center for Life Sciences, Harbin Institute of Technology (HIT), Harbin, 150001, P. R. China.

Small Methods
|January 15, 2025
PubMed
Summary
This summary is machine-generated.

Researchers are advancing chemo-optogenetics for precise cellular control. New methods allow multi-wavelength light control and complex cellular network studies.

Keywords:
cell signalingchemically induced proximitychemo‐optogeneticscyclic cell‐penetrating peptidenanobody conjugatephotoactivationphotoswitchable

More Related Videos

Chemical Dimerization-Induced Protein Condensates on Telomeres
08:52

Chemical Dimerization-Induced Protein Condensates on Telomeres

Published on: April 12, 2021

3.1K
Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

8.7K

Related Experiment Videos

Last Updated: Jun 2, 2025

Author Spotlight: Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos
12:35

Author Spotlight: Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos

Published on: April 14, 2023

1.3K
Chemical Dimerization-Induced Protein Condensates on Telomeres
08:52

Chemical Dimerization-Induced Protein Condensates on Telomeres

Published on: April 12, 2021

3.1K
Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

8.7K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Optogenetics

Background:

  • Light provides precise, non-invasive control over cellular functions.
  • Chemo-optogenetic dimerization, using photo-triggered chemical inducers of dimerization (pCIDs), is a key tool for spatiotemporal regulation.
  • Existing methods typically offer a single ON or OFF switch for cellular activity.

Purpose of the Study:

  • To introduce and discuss advanced chemo-optogenetic tools for sophisticated cellular regulation.
  • To highlight novel approaches enabling multi-layer control and complex cellular network investigations.
  • To explore the potential of these advancements in studying multi-functional proteins.

Main Methods:

  • Development and application of photo-triggered chemical inducers of dimerization (pCIDs).
  • Utilizing different wavelengths of light for distinct cellular control.
  • Employing nanobody-tethered photodimerizers for targeted regulation.
  • Investigating multi-layer control of cellular activities.

Main Results:

  • Demonstration of sophisticated ON/OFF control using distinct light wavelengths.
  • Implementation of multi-layer regulatory systems for complex cellular processes.
  • Successful application of nanobody-tethered photodimerizers.
  • Enhanced ability to study multi-functional proteins and cellular networks.

Conclusions:

  • Advanced chemo-optogenetic tools offer unprecedented spatiotemporal control over cellular functions.
  • These novel approaches expand the possibilities for studying complex biological systems.
  • The development of sophisticated light-controlled dimerization techniques opens new avenues in chemical biology research.