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Mind the gap in kidney care: translating what we know into what we do
Valerie A Luyckx1,2,3, Katherine R Tuttle3,4,5, Dina Abdellatif6
1Department of Public and Global Health, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
Abstract:
Historically, it takes an average of 17 years to move new treatments from clinical evidence to daily practice. Given the highly effective treatments now available to prevent or delay kidney disease onset and progression, this is far too long. The time is now to narrow the gap between what we know and what we do. Clear guidelines exist for the prevention and management of common risk factors for kidney disease, such as hypertension and diabetes, but only a fraction of people with these conditions worldwide are diagnosed, and even fewer are treated to target. Similarly, the vast majority of people living with kidney disease are unaware of their condition, because in the early stages it is often silent. Even among patients who have been diagnosed, many do not receive appropriate treatment for kidney disease. Considering the serious consequences of kidney disease progression, kidney failure, or death, it is imperative that treatments are initiated early and appropriately. Opportunities to diagnose and treat kidney disease early must be maximized beginning at the primary care level. Many systematic barriers exist, ranging from patient to clinician to health systems to societal factors. To preserve and improve kidney health for everyone everywhere, each of these barriers must be acknowledged so that sustainable solutions are developed and implemented without further delay.
Insights
It takes too long to implement new kidney disease treatments. Early diagnosis and treatment are crucial but hindered by many barriers, requiring immediate action to improve global kidney health.
Area of Science:
- Nephrology
- Public Health
- Health Services Research
Background:
- A significant delay exists in translating kidney disease research into clinical practice.
- Effective treatments are available to prevent or slow kidney disease, yet implementation lags.
- Many individuals with risk factors like hypertension and diabetes, or kidney disease itself, remain undiagnosed or undertreated.
Purpose of the Study:
- To highlight the critical need to accelerate the adoption of evidence-based kidney disease treatments.
- To identify barriers preventing timely diagnosis and management of kidney disease.
- To advocate for maximizing early diagnosis and treatment opportunities, particularly at the primary care level.
Main Methods:
- This study is a review and synthesis of current knowledge on kidney disease treatment implementation.
- It analyzes systemic barriers across patient, clinician, health system, and societal levels.
- The focus is on identifying gaps between established guidelines and clinical practice.
Main Results:
- A substantial gap persists between kidney disease knowledge and its application in patient care.
- Diagnosis rates for hypertension, diabetes, and kidney disease are low globally.
- Even diagnosed patients often do not receive optimal kidney disease management.
Conclusions:
- Urgent action is needed to reduce the 17-year average delay in implementing kidney disease treatments.
- Addressing multifaceted barriers is essential for improving early diagnosis and appropriate management.
- Sustainable solutions must be developed and implemented to preserve and enhance global kidney health.
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