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Updated: Jun 2, 2025

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
Published on: November 10, 2023
Schizophrenia and Bone Marrow Disorders: An Emerging Clinical Association
Jayalekshmi Jayakumar1, Manasa Ginjupalli1, Aju Kalaivani Babu2
1Department of Internal Medicine, The Brooklyn Hospital Center, New York, USA.
Abstract:
Schizophrenia is a chronic psychiatric disorder with a complex etiology involving genetic, neurobiological, and environmental factors. Many individuals with schizophrenia experience treatment resistance despite advances in pharmacologic and non-pharmacologic interventions. Immune dysregulation, characterized by altered cytokine levels, immune-related gene expression, and neuroinflammation, plays a critical role in schizophrenia's pathogenesis. Furthermore, associations between schizophrenia and bone marrow malignancies, with documentation of remission of treatment-resistant schizophrenia following bone marrow transplantation for malignancies, are emerging. This review synthesizes findings on the immunological underpinnings of schizophrenia, explores potential connections with bone marrow dysfunction, and evaluates the therapeutic potential of immune-modulating approaches, including bone marrow transplantation. By highlighting these connections, the study aims to advance understanding and stimulate prospective research into innovative treatments for this debilitating condition.
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