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Prospective study on the role of preoperative mannitol in capsulorhexis and reducing intraoperative complications in

Zhiqiao Liang¹, Hongyan Li¹, Xianru Hou¹

¹Department of Ophthalmology, Peking University People's Hospital; Eye Diseases and Optometry Institute; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases; College of Optometry, Peking University Health Science Center. Address: No. 11 Xizhimen South Street, Xicheng District, Beijing, China.

The Journal of International Medical Research

|January 16, 2025

Summary

This summary is machine-generated.

Preoperative intravenous mannitol significantly reduces capsulorhexis time and intraoperative complications in primary angle-closure glaucoma (PACG) surgery. This intervention improves surgical outcomes for PACG patients.

Keywords:

Intravenous mannitol capsulorhexis goniosynechialysis intraoperative complication phacoemulsification primary angle-closure disease zonulopathy

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Area of Science:

Ophthalmology
Glaucoma Surgery
Surgical Techniques

Background:

Primary angle-closure glaucoma (PACG) presents unique surgical challenges.
The capsulorhexis stage is critical and prone to complications in PACG.
Optimizing surgical conditions is essential for favorable outcomes.

Purpose of the Study:

To assess the impact of preoperative intravenous mannitol on the capsulorhexis procedure.
To evaluate the effect of mannitol on intraoperative complications during PACG surgery.
To identify factors influencing the capsulorhexis process in PACG.

Main Methods:

Prospective randomized controlled trial involving 65 PACG eyes.
Comparison between a mannitol group and a control group.
Recording of capsulorhexis duration, forceps grasps, and complications.

Main Results:

The mannitol group demonstrated significantly shorter capsulorhexis duration and fewer capsule grasps.
All intraoperative complications (18.2%) were observed in the control group.
Intravenous mannitol was associated with reduced capsulorhexis duration (OR = -14.263).

Conclusions:

Preoperative intravenous mannitol effectively reduces intraoperative complications in PACG surgery.
Mannitol administration improves surgical efficiency and potentially postoperative outcomes.
Anterior chamber depth, incision characteristics, and zonule status are key factors in capsulorhexis.