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Related Experiment Video

Updated: May 5, 2026

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
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Ginsenoside Rg3 in Cancer Research: Current Trends and Future Prospects - A Review.

Auwal Ibrahim Tanko1, Salman Hosawi1, Ehssan Moglad2

  • 1Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.

Current Medicinal Chemistry
|January 16, 2025
PubMed
Summary
This summary is machine-generated.

Ginsenoside Rg3, a natural compound from ginseng, shows promise in cancer treatment by boosting immunity and inhibiting cancer growth. It may enhance chemotherapy effectiveness and reduce side effects.

Keywords:
Ginsenoside Rg3chemotherapycombinatorial therapyginseng.sensitivitytoxicity

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Area of Science:

  • Oncology
  • Natural Products Chemistry
  • Pharmacology

Background:

  • Cancer remains a leading global health challenge with unsatisfactory treatment outcomes.
  • Conventional chemotherapy faces limitations due to severe side effects, limited efficacy, and drug resistance.
  • Ginsenoside Rg3, a compound from Panax ginseng, is emerging as a promising natural therapeutic agent for cancer.

Purpose of the Study:

  • To review the current status of ginsenoside Rg3 in cancer research.
  • To elucidate the multifaceted mechanisms of ginsenoside Rg3 in cancer therapy.
  • To explore its potential in revolutionizing cancer treatment strategies.

Main Methods:

  • Literature review of preclinical and clinical studies on ginsenoside Rg3.
  • Analysis of proposed mechanisms including immune enhancement, anti-proliferation, anti-metastasis, apoptosis induction, and anti-angiogenesis.
  • Investigation of its role in epigenetic modification, epithelial-mesenchymal transition (EMT), and non-coding RNA regulation.

Main Results:

  • Ginsenoside Rg3 exhibits diverse anti-cancer activities.
  • It demonstrates potential in potentiating conventional cancer therapies and mitigating adverse effects through synergistic interactions.
  • Its mechanisms involve complex biological pathways including immune modulation and cellular process regulation.

Conclusions:

  • Ginsenoside Rg3 holds significant therapeutic potential in oncology.
  • Combinatorial approaches and nano-based targeted delivery systems may enhance its clinical efficacy.
  • Further research is warranted to fully harness its capabilities in cancer treatment.