The Dorsolateral Prefrontal Cortex: A High-level Hub for Allostatic Cardiovascular Control

Area of Science:

• Neuroscience
• Neuromodulation
• Cognitive Science

Background:

• The dorsolateral prefrontal cortex (dlPFC) is a key target for neuromodulation in neuropsychiatric disorders.
• The precise mechanisms underlying dlPFC's therapeutic effects remain unclear.
• Understanding dlPFC function is crucial for developing effective brain stimulation treatments.

Purpose of the Study:

• To propose a model integrating dlPFC functions in uncertainty management, movement facilitation, and cardiovascular control.
• To review current evidence supporting the proposed dlPFC model.
• To accelerate the development of neuromodulation technologies for brain disorders.

Main Methods:

• Literature review and synthesis of existing evidence.
• Development of a conceptual model for dlPFC function.
• Discussion of the state-of-the-art in brain stimulation and recording technologies.

Main Results:

• The dlPFC acts as a high-level center integrating cognitive, motor, and autonomic functions.
• This integration supports adaptive behavioral responses in various contexts.
• Evidence supports the dlPFC's role in managing uncertainty and facilitating movement.

Conclusions:

• The proposed model provides a framework for understanding dlPFC's role in brain disorders.
• This understanding can guide the development of targeted neuromodulation therapies.
• Advancements in brain stimulation are essential for treating mood, sleep, and cognitive disorders in aging individuals.