Clinical Outcomes in a Multicenter Cohort Involving 919 Patients With Hypertriglyceridemia-Associated Acute...

Area of Science:

• Gastroenterology
• Internal Medicine
• Critical Care Medicine

Background:

• Hypertriglyceridemia-associated acute pancreatitis (HTG-AP) is a common cause of acute pancreatitis (AP) globally.
• Previous studies on the severity of HTG-AP compared to other etiologies have yielded inconsistent results due to confounding factors.

Purpose of the Study:

• To investigate the risk and risk factors associated with developing severe AP in patients with HTG-AP.
• To develop and validate a predictive model for severe AP in the context of HTG-AP.

Main Methods:

• A multicenter cohort study included 4,378 patients with AP from January 2013 to December 2023.
• Multivariable logistic regression was used to identify risk factors for severe AP after adjusting for confounders.
• A prediction model was developed and validated using training and testing datasets.

Main Results:

• HTG-AP patients exhibited a significantly higher risk of severe AP (OR: 1.897) and organ failure compared to other AP etiologies.
• Key risk factors for severe AP in HTG-AP patients included advanced age, elevated fasting blood glucose, high white blood cell counts, and pleural effusion.
• The developed prediction model showed strong performance with an AUC of 0.837 (training) and 0.883 (testing).

Conclusions:

• HTG-AP is associated with an increased risk of severe AP and organ failure.
• A validated risk prediction model effectively stratifies patients for severe HTG-AP, enabling targeted management.