Related Experiment Video

Updated: Jun 2, 2025

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases
06:30

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases

Published on: August 27, 2021

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E3 ubiquitin ligase SYVN1 as a promising therapeutic target for diverse human diseases

Li Zhu1, Yong-Ping Liu2, Yuan-Wang1

  • 1Graduate School of Dalian Medical University, Dalian, Liaoning 116000, China; State Key Laboratory of Frigid Zone Cardiovascular Disease, Department of Cardiovascular Surgery, General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, China.

Pharmacological Research
|January 16, 2025
PubMed

Insights

The E3 ubiquitin ligase SYVN1 is vital for cellular balance and impacts gene expression, signaling, and cell death. Dysregulation of SYVN1 contributes to diseases like cancer and neurological disorders.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Cellular Biology

Background:

  • Mammalian E3 ubiquitin ligases are critical for maintaining cellular homeostasis through protein ubiquitination and signaling.
  • SYVN1, a specific E3 ubiquitin ligase, regulates diverse biological processes including gene expression, signaling pathways, and cell death.

Purpose of the Study:

  • To review recent findings on the physiological and pathophysiological roles of SYVN1.
  • To elucidate the mechanisms underlying SYVN1's involvement in human diseases.
  • To identify potential therapeutic strategies and future research directions for SYVN1.

Main Methods:

  • Literature review and synthesis of recent scientific findings.
  • Analysis of SYVN1's regulatory functions in various biological contexts.
  • Examination of SYVN1's role in both normal physiology and disease pathogenesis.

Main Results:

  • SYVN1 plays a significant role in regulating gene expression, signaling pathways, and cell death.
  • SYVN1 is implicated in the pathogenesis of oncogenesis, cardiovascular disorders, immune regulation, skeletal anomalies, and neurological diseases.
  • Understanding SYVN1's mechanisms offers insights into disease progression.

Conclusions:

  • SYVN1 is a key regulator with implications for numerous human diseases.
  • Further investigation of SYVN1 provides opportunities for novel therapeutic strategies.
  • SYVN1 research offers promising directions for future drug development.
Keywords:
Cancer diseaseE3 ubiquitin ligaseSYVN1

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