Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Parathyroid Glands

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

FOS gene fusions in osteosarcoma raise the hypothesis of malignant transformation of osteoblastoma.

Virchows Archiv : an international journal of pathology·2025

Same author

French expert consensus statement on diagnosis and management of primary hyperparathyroidism.

Annales d'endocrinologie·2025

Same author

Insights Into Non-Classic Primary Bone Sarcomas in Children, Adolescents, and Young Adults: A French Descriptive Study.

Pediatric blood & cancer·2025

Same author

[New approaches for pathology teaching in undergraduate medical studies, the University Paris-Saclay experience].

Annales de pathologie·2025

Same author

Caesarean section scar: Histological analysis on hysterectomy specimen. A pilot study.

European journal of obstetrics, gynecology, and reproductive biology·2024

Same author

Differentiating pathologic parathyroid glands from thyroid nodules on neck ultrasound: the PARATH-US cross-sectional study.

The Lancet regional health. Europe·2023

Search research articles

Related Experiment Video

Updated: Jun 14, 2025

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

Chapter 13: Changes in 2022 WHO classification of parathyroid tumors.

Margot Dupeux¹, Sébastien Aubert²

¹Service d'anatomie pathologique, centre hospitalier de Bicêtre, université Paris-Saclay, AP-HP, Le Kremlin-Bicêtre, France.

Annales D'Endocrinologie

|January 16, 2025

Summary

The 2022 WHO classification for parathyroid tumors integrates genetic data, aiding in identifying tumors with genetic abnormalities. This improves patient management through better histological and molecular characterization by pathologists.

Keywords:

Atypical parathyroid tumor Multi-glandular parathyroid disease Parafibromin Parathyroid adenoma Parathyroid carcinoma WHO classification

More Related Videos

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

Related Experiment Videos

Last Updated: Jun 14, 2025

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

Area of Science:

Endocrine Pathology
Oncology
Genetics

Background:

The 2022 World Health Organization (WHO) classification of parathyroid tumors reflects advances in understanding tumor pathophysiology.
Genetic sequencing data has become crucial in identifying specific parathyroid tumor subtypes.

Purpose of the Study:

To summarize the key updates in the 2022 WHO classification of parathyroid tumors.
To emphasize the role of histological features and molecular markers in diagnosis and management.

Main Methods:

Review of the latest WHO classification guidelines for parathyroid tumors.
Integration of recent findings on parathyroid tumor genetics and pathophysiology.
Highlighting the utility of immunohistochemical markers and molecular screening.

Main Results:

The 2022 classification incorporates genetic insights, linking histological features to underlying genetic abnormalities.
Specific histological characteristics are now recognized as potential indicators of genetic alterations.
Immunohistochemistry and molecular diagnostics are vital for precise characterization.

Conclusions:

The updated classification underscores the importance of genetic information in parathyroid tumor diagnosis.
Accurate pathological characterization requires comprehensive clinical and paraclinical data.
This facilitates improved patient management strategies based on tumor genetics.