Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Quality Assurance01:19

Quality Assurance

114
Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
114
Data Validation01:15

Data Validation

141
Method validation is a crucial process in analytical chemistry designed to confirm that a given method consistently produces reliable and high-quality results. This process is essential when a method is applied to different sample matrices or when procedural modifications are made, ensuring that the results meet acceptable standards across various applications.
Key parameters for method validation include:
141

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Error identification in external beam radiotherapy using diode-based in vivo dosimetry during the transition from 2D to 3DCRT in Uganda.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same author

Radiation therapy for cervical cancer in Uganda: a practice guideline.

Ecancermedicalscience·2026
Same author

Feasibility and impact of knowledge-based automated radiotherapy treatment planning in low- and middle-income countries.

Ecancermedicalscience·2026
Same author

Impact of Waiting Time and Treatment Duration on Short-Term Outcomes for Patients With Locally Advanced Cervical Cancer at the Uganda Cancer Institute: The Challenges in Resource-Limited Settings.

JCO global oncology·2025
Same author

SMART-HERBALOMICS: An innovative multi-omics approach to studying medicinal plants grown in controlled systems such as phytotrons.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2025
Same author

Direct somatic embryogenesis induction in Aspilia Africana (Pers.) C. D. Adams, and assessment of genetic homogeneity and physiology of regenerants.

Scientific reports·2025

Related Experiment Video

Updated: Jun 2, 2025

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
06:57

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection

Published on: September 22, 2023

924

Validation of clearcalc for efficient patient specific QA.

Ignatius Komakech1, Denis Okello2, Awusi Kavuma3

  • 1Radiation Oncology Division, Uganda Cancer Institute, Kampala, Uganda; Department of Physics, Makerere University, Kampala, Uganda.

Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists
|January 16, 2025
PubMed
Summary

ClearCalc (ICS) software was validated for independent checks of radiotherapy treatment planning system (TPS) calculations. This promising tool offers significant time savings for patient-specific quality assurance (QA).

Keywords:
Gamma evaluationIndependent calculationPatient specific QAPretreatment QA

More Related Videos

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

15.7K
Split Point Analysis and Uncertainty Quantification of Thermal-Optical Organic/Elemental Carbon Measurements
10:22

Split Point Analysis and Uncertainty Quantification of Thermal-Optical Organic/Elemental Carbon Measurements

Published on: September 7, 2019

8.2K

Related Experiment Videos

Last Updated: Jun 2, 2025

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
06:57

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection

Published on: September 22, 2023

924
Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

15.7K
Split Point Analysis and Uncertainty Quantification of Thermal-Optical Organic/Elemental Carbon Measurements
10:22

Split Point Analysis and Uncertainty Quantification of Thermal-Optical Organic/Elemental Carbon Measurements

Published on: September 7, 2019

8.2K

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Radiotherapy Quality Assurance

Background:

  • Uganda's sole radiotherapy center faces high patient volume, limiting time for pretreatment quality assurance (QA).
  • Efficient and reliable pretreatment QA is crucial for safe and accurate radiation therapy delivery.

Purpose of the Study:

  • To validate ClearCalc (ICS), an independent software, for second checks of treatment planning system (TPS) calculations.
  • To assess the time-saving potential of ICS for patient-specific QA in a busy radiotherapy center.

Main Methods:

  • Validation using phantom test plans (square, irregular, open, wedged fields) comparing ICS calculations with TPS and measured doses.
  • Validation on clinically approved treatment plans, comparing ICS calculations with TPS and pretreatment QA measurements using electronic portal imaging devices (EPIDs).
  • Analysis using Gamma passing criteria of 3%/3 mm and 3%/2 mm.

Main Results:

  • Test plan results were within 3.0% passing level, with minor outliers.
  • Clinically approved plans showed good agreement for monitor units (MUs) (0.2 ± 1.8%) and doses.
  • High 3D mean Gamma pass rates (98.1±1.6% for 3%/2 mm, 98.4±1.0% for 3%/3 mm) were achieved.

Conclusions:

  • ClearCalc (ICS) is validated for both phantom and clinical treatment plans.
  • ICS-based patient-specific QA is quick, promising, and offers significant time savings.
  • The validated ICS can potentially increase machine time available for patient treatments.