Biofluid-Permeable and Erosion-Resistant Wireless Neural-Electronic Interfaces for Neurohomeostasis Modulation

Area of Science:

• Biomedical Engineering
• Neuroscience
• Materials Science

Background:

• Drug-refractory neurological disorders require advanced treatment strategies.
• Existing neural-electronic interfaces face challenges with biofluid compatibility, leading to device failure and adverse tissue reactions.
• A need exists for robust interfaces that can withstand aggressive biofluid environments for sustained therapeutic effects.

Purpose of the Study:

• To develop a biofluid-permeable and erosion-resistant wireless neural-electronic interface (BNEI).
• To enable stable, long-term wireless neuromodulation for treating neurological conditions.
• To demonstrate the clinical efficacy of the BNEI in peripheral neuropathy and epilepsy.

Main Methods:

• Fabrication of a BNEI using a flexible 3D interconnected poly(l-lactide) fibrous network with aligned piezoelectric molecular chains.
• Engineering the material architecture to enhance water barrier properties and piezoelectric efficiency.
• Conducting a 3-month clinical trial to assess therapeutic outcomes in patients.

Main Results:

• The BNEI demonstrated improved water barrier properties and efficient conversion of acoustic vibrations to electrical signals.
• The device achieved long-term stable and wireless neuromodulation in a clinical setting.
• Significant acceleration of nerve regeneration in peripheral neuropathy and seizure suppression in temporal lobe epilepsy were observed.

Conclusions:

• The developed BNEI offers a clinically scalable solution for wireless neuromodulation.
• This technology is broadly applicable for modulating neurohomeostasis in both peripheral and central nervous systems.
• The BNEI represents a significant advancement in treating drug-refractory neurological disorders.