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Plasma Human Cartilage Glycoprotein-39 and Cognitive Impairment After Acute Ischemic Stroke

Ziyi Wang1, Kaixin Zhang2,3, Chongke Zhong3

  • 1Department of Neurology, Affiliated Hospital of Nantong University Medical School of Nantong University Nantong China.

Journal of the American Heart Association
|January 17, 2025
PubMed

Insights

Elevated levels of human cartilage glycoprotein-39 (YKL-40) are linked to a higher risk of cognitive impairment after acute ischemic stroke. This finding suggests YKL-40 may be a useful biomarker for post-stroke cognitive decline.

Area of Science:

  • Biomarkers
  • Neurology
  • Cardiovascular Research

Background:

  • Acute ischemic stroke poses a significant risk for developing cognitive impairment.
  • Human cartilage glycoprotein-39 (YKL-40) is a potential inflammatory biomarker.
  • The association between YKL-40 and post-stroke cognitive impairment requires further investigation.

Purpose of the Study:

  • To evaluate the association between plasma YKL-40 levels and cognitive impairment at 3 months post-acute ischemic stroke.
  • To determine if YKL-40 can serve as a predictive biomarker for cognitive decline after stroke.

Main Methods:

  • Plasma YKL-40 levels were measured in 604 patients from the China Antihypertensive Trial in Acute Ischemic Stroke.
  • Cognitive function was assessed at 3 months using the Mini-Mental State Examination and Montreal Cognitive Assessment.
  • Statistical analyses included quartile comparisons, regression models, and ROC curve analysis.

Main Results:

  • Patients in the highest quartile of YKL-40 had a 2.01-fold increased risk of cognitive impairment (MMSE score).
  • Each 1 SD increase in YKL-40 was associated with a 28% increased risk of cognitive impairment.
  • YKL-40 improved the discriminatory power of conventional risk factors for predicting cognitive impairment.

Conclusions:

  • Elevated plasma YKL-40 levels are significantly associated with an increased risk of cognitive impairment 3 months after acute ischemic stroke.
  • YKL-40 may serve as a valuable biomarker for identifying patients at higher risk of post-stroke cognitive impairment.
Abstract

Keywords:
YKL‐40biomarkerscognitive impairmentischemic strokeprognosis

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