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Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
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Random noise promotes slow heterogeneous synaptic dynamics important for robust working memory computation.

Nuttida Rungratsameetaweemana1,2, Robert Kim2,3, Thiparat Chotibut4

  • 1Department of Biomedical Engineering, Columbia University, New York, NY 10027.

Proceedings of the National Academy of Sciences of the United States of America
|January 17, 2025
PubMed
Summary
This summary is machine-generated.

Adding random noise to recurrent neural networks (RNNs) surprisingly speeds up training and improves working memory performance. This noise enhances synaptic function in inhibitory neurons, crucial for stable information processing.

Keywords:
neural dynamicsrecurrent neural networkworking memory

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Area of Science:

  • Computational neuroscience
  • Cognitive modeling

Background:

  • Recurrent neural networks (RNNs) model cortical circuits for cognitive tasks.
  • Training RNNs for working memory remains challenging due to information maintenance demands.

Purpose of the Study:

  • Investigate the impact of random noise on RNNs, particularly for working memory.
  • Explore how noise influences neural dynamics and cognitive functions in artificial neural networks.

Main Methods:

  • Trained RNNs with varying levels of random noise on cognitive tasks, including working memory.
  • Analyzed changes in network dynamics, synaptic properties, and performance metrics.

Main Results:

  • Random noise accelerated RNN training and enhanced working memory task stability and performance.
  • Noise increased synaptic decay time constants in inhibitory units, slowing activity decay.
  • This led to more robust maintenance of stimulus-specific information.

Conclusions:

  • Random noise plays a critical role in enhancing RNN performance on working memory tasks.
  • Noise-induced changes in inhibitory neuron dynamics support stable information processing.
  • Inherent neural variability may be key for specialized inhibitory functions in higher cortical areas.