Related Experiment Video

Updated: Jun 2, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

2.9K

Effects of high-sensitivity C-reactive protein and left ventricular hypertrophy on cognitive function in hemodialysis

Yu Zhang1, Yu-Lu Gu1, Wan-Fen Zhang1

  • 1Department of Nephrology, the Affiliated Changzhou Second People's Hospital with Nanjing Medical University, Changzhou, China.

Renal Failure
|January 17, 2025
PubMed

Insights

High-sensitivity C-reactive protein (hs-CRP) and left ventricular hypertrophy (LVH) significantly increase cognitive impairment (CI) risk in hemodialysis patients. Managing these factors may help prevent CI in this population.

Area of Science:

  • Nephrology
  • Cardiology
  • Neurology
  • Biomarkers

Background:

  • Cognitive impairment (CI) is a prevalent complication in patients undergoing hemodialysis (HD).
  • Inflammation, indicated by high-sensitivity C-reactive protein (hs-CRP), and cardiac structural changes like left ventricular hypertrophy (LVH) are common in HD patients and may influence cognitive function.

Purpose of the Study:

  • To investigate the individual and combined effects of hs-CRP and LVH on cognitive function in hemodialysis patients.
  • To explore the relationship between hs-CRP levels, LVH status, and the risk of cognitive impairment (CI) in this cohort.

Main Methods:

  • A cross-sectional study involving 232 hemodialysis patients.
  • Cognitive function was assessed using the Beijing version of the Montreal Cognitive Assessment (MoCA-BJ).
  • Logistic regression and EpiR package were used to analyze risk factors, including hs-CRP levels (categorized as low, intermediate, and high risk) and LVH status, and their synergistic effect on CI.

Main Results:

  • Over half (52.59%) of the HD patients exhibited cognitive impairment (CI).
  • Independent risk factors for CI included older age (OR = 1.048), left ventricular hypertrophy (LVH) (OR = 3.741), and high hs-CRP levels (>3 mg/L) (OR = 3.238).
  • A significant synergistic effect was observed between high hs-CRP levels and LVH in increasing the risk of CI.

Conclusions:

  • Age, LVH, and high hs-CRP levels are independent risk factors for cognitive impairment (CI) in hemodialysis patients.
  • Patients with both high hs-CRP and LVH face a substantially elevated risk of CI.
  • Strategies aimed at reducing hs-CRP levels and preventing LVH may be crucial for mitigating cognitive decline in hemodialysis patients.
Abstract

Keywords:
Hemodialysiscognitive impairmenthigh-sensitivity C-reactive proteinleft ventricular hypertrophysynergy

More Related Videos

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis04:36

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Published on: October 2, 2020

2.1K
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

20.3K

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
55
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
378
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
338
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
51
Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
32.9K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K