Related Experiment Video
Updated: Jun 2, 2025
06:41
High-Throughput Identification of Resistance to Pseudomonas syringae pv. Tomato in Tomato using Seedling Flood Assay
Published on: March 10, 2020
9.5K
What does cancer screening have to do with tomato growing?
Miyo K Chatanaka1, Eleftherios P Diamandis2
1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Clinical Chemistry and Laboratory Medicine
|January 17, 2025
Summary
Cancer screening tests offer limited life extension benefits. Colorectal screening provides modest gains, while others show no significant impact, questioning current early detection strategies.
Area of Science:
- Oncology
- Preventive Medicine
- Clinical Trials
Background:
- Cancer screening is a key strategy for cancer control.
- Evidence for the effectiveness of many screening tests is limited.
- The United States Preventive Services Task Force (USPSTF) recommends screening for five cancers.
Purpose of the Study:
- To evaluate the life-extending benefits of common cancer screening tests.
- To determine if current cancer screening strategies significantly prolong life.
- To inform potential modifications in cancer treatment strategies.
Main Methods:
- Meta-analysis of 18 large randomized clinical trials.
- Inclusion of over two million participants.
- Estimation of lifetime gained from various cancer screening methods.
Main Results:
- Sigmoidoscopy for colorectal cancer screening extended life by 110 days.
- Fecal testing and mammography showed no significant life extension.
- Prostate and lung cancer screening provided modest, non-significant life extension (37 and 107 days, respectively).
Conclusions:
- Current cancer screening strategies do not significantly prolong life.
- The limited efficacy suggests a need to re-evaluate screening protocols.
- Modified post-detection cancer treatment strategies may be beneficial, potentially avoiding screening side effects.
Keywords:
Galleri testbiomarkerscancer at pubertycancer screeningmeta-analysismulti-cancer early detectionMore Related Videos
15:25Tomato Analyzer: A Useful Software Application to Collect Accurate and Detailed Morphological and Colorimetric Data from Two-dimensional Objects
Published on: March 16, 2010
26.3K
06:26An Efficient Clearing Protocol for the Study of Seed Development in Tomato Solanum lycopersicum L.
Published on: September 7, 2022
4.0K
Related Concept Videos
02:59Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
02:07Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
03:03mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
7.3K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.3K
02:43Mouse Models of Cancer Study
5.5K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K
02:18Cancer
47.7K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
47.7K