Ubiquitination-related Gene UBTD1 Mediates Poor Prognosis of Colorectal Cancer and Affects Colorectal Cancer Cell Proliferation and Ferroptosis
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View abstract on PubMed
Summary
This summary is machine-generated.Ubiquitin domain-containing protein 1 (UBTD1) is a key gene in colorectal cancer (CRC) prognosis, impacting immune escape and ferroptosis. Targeting UBTD1 with drugs like telatinib shows therapeutic potential for CRC.
Area Of Science
- Oncology
- Molecular Biology
- Immunology
Background
- Colorectal cancer (CRC) is a leading global cancer, influenced by genetic factors.
- Ubiquitination pathways significantly regulate the tumor microenvironment and immune responses in CRC pathogenesis.
- Understanding ubiquitination-associated genes is crucial for CRC prognosis and treatment strategies.
Purpose Of The Study
- To investigate the role of ubiquitination-associated genes in colorectal cancer (CRC) prognosis.
- To identify specific genes, like UBTD1, that influence CRC progression and the tumor immune microenvironment.
- To explore the potential of UBTD1 as a prognostic marker and therapeutic target in CRC.
Main Methods
- Bioinformatics and single-cell analyses were used to identify the ubiquitination-related gene UBTD1.
- UBTD1's prognostic and immune checkpoint correlation in CRC was analyzed.
- Experimental validation included immunohistochemistry, gene knockout, western blot, cell cloning, and immunofluorescence to assess UBTD1's role in CRC and ferroptosis.
Main Results
- UBTD1 was identified as a significant prognostic and predictive gene for colorectal cancer (CRC).
- High UBTD1 expression correlates with increased immune checkpoints, promoting immune escape and inhibiting ferroptosis.
- Telatinib emerged as a potential therapeutic agent targeting UBTD1 in CRC.
Conclusions
- UBTD1 serves as a prognostic marker in colorectal cancer (CRC), influencing ubiquitination and the tumor immune microenvironment.
- UBTD1 plays a role in modulating ferroptosis in CRC.
- Targeting UBTD1 presents a potential therapeutic avenue for colorectal cancer.
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