Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

78
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
78
Positron Emission Tomography01:29

Positron Emission Tomography

4.0K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.0K
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

82
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
82

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Monitoring glioblastoma dynamics during chemoradiation on the 1.5 T magnetic resonance imaging-linear accelerator.

Clinical and translational radiation oncology·2026
Same author

A Phase 1 and Biodistribution study of Ifabotuzumab, a humanized agonistic EphA3-targeted antibody, in patients with recurrent glioblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Identifying factors associated with sleep disturbance among adults seeking outpatient psychiatric services for anxiety and related disorders.

Bulletin of the Menninger Clinic·2026
Same author

Cancer workforce-a global crisis: a Lancet Oncology Commission.

The Lancet. Oncology·2026
Same author

Estimating total and diagnosed global cancer incidence and stage distribution from 1990 to 2050: a simulation-based analysis of 17 cancers.

The Lancet. Oncology·2026
Same author

Estimating global cancer survival and mortality from 1990 to 2050: a simulation-based analysis of 17 cancers.

The Lancet. Oncology·2026

Related Experiment Video

Updated: Jun 2, 2025

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

298

A Method for Validating PET and SPECT Cameras for Quantitative Clinical Imaging Trials Using Novel Radionuclides.

Dale L Bailey1,2, Kathy P Willowson3,4, Graeme O'Keefe5

  • 1Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, New South Wales, Australia; dale.bailey@sydney.edu.au.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|January 17, 2025
PubMed
Summary

A new methodology calibrates and verifies quantitative accuracy for PET and SPECT imaging in clinical trials using nonstandard radionuclides like iodine-124 and iodine-131. This ensures reliable data quality assurance for advanced nuclear medicine research.

Keywords:
PETSPECTclinical trialssite validation

More Related Videos

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

9.8K
Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases
11:03

Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases

Published on: May 29, 2017

9.9K

Related Experiment Videos

Last Updated: Jun 2, 2025

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
09:55

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

Published on: October 4, 2024

298
A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

9.8K
Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases
11:03

Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases

Published on: May 29, 2017

9.9K

Area of Science:

  • Nuclear Medicine
  • Medical Imaging
  • Radiochemistry

Background:

  • Quantitative accuracy and quality assurance are critical for Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) in clinical trials.
  • Standard calibration protocols often rely on radionuclides like Fluorine-18, necessitating new methods for nonstandard radionuclides, particularly those with longer half-lives.

Purpose of the Study:

  • To develop and report a methodology for calibrating and verifying the quantitative accuracy and quality assurance of PET and SPECT imaging systems.
  • To adapt these methods for use with nonstandard radionuclides, specifically those with longer half-lives, in the context of clinical imaging trials.

Main Methods:

  • A three-step calibration protocol was implemented: verification with a standard radionuclide, testing the novel radionuclide in a simple geometry, and assessment in a complex geometry using the NEMA NU-2 IEC image-quality phantom.
  • The methodology was exemplified using Iodine-124 (PET) and Iodine-131 (SPECT), requiring whole-body tomographic imaging with low-dose CT.
  • PET system calibration involved dose calibrator adjustments for non-standard radionuclides, while SPECT calibration used independent sensitivity measurements at a core laboratory.

Main Results:

  • Seven Australian sites successfully qualified 10 PET/CT scanners for Iodine-124 imaging and 8 SPECT/CT systems for Iodine-131 imaging.
  • One PET/CT system exceeded the specified quantitative accuracy (SUVavg of 1.0 ± 0.05).
  • All qualified SPECT/CT systems achieved quantitative accuracy within ±10% of the true radioactivity concentration.

Conclusions:

  • A generalizable methodology for calibrating and validating PET and SPECT systems for quantitative imaging in clinical trials has been successfully established.
  • The developed procedures are relatively simple and can be implemented by on-site staff with equipment provided by clinical trials organizations.
  • This approach enhances the reliability of quantitative imaging data in clinical trials using a wider range of radionuclides.