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Published on: September 17, 2014
Strategies for long-acting drug design
Muqi Huang1, Zheng Cai1, Shuwen Liu1,2
1School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Abstract:
With advances of drug design and preparation technology, the development of long-acting drugs has become an important research focus in precision medicine and chronic disease management. These drugs are designed to improve the patients' compliance and quality of life by achieving prolonged maintenance of an effective drug concentration in the body with a reduced dosing frequency. Small molecule drugs, monoclonal antibodies and nucleic acid drugs all have their own difficulties in achieving long actions, which can be especially challenging for the latter two because of their structural complexity. This review provides an overview of the strategies for designing long-acting small molecule drugs, monoclonal antibodies, and nucleic acid drugs.
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