Determining event-related desynchronization onset latency of foot dorsiflexion in people with multiple sclerosis...

Multiple sclerosis (MS) is a disorder in which the body's immune system attacks structures of the central nervous system, resulting in lesions that can occur throughout the brain and spinal cord. Cortical lesions, in particular, can contribute to motor dysfunction. Walking disability is reported as the main impairment by people with MS (pwMS), often due to limited ankle movement. This study explored the event-related desynchronization (ERD) onset latency of the sensorimotor rhythms during foot dorsiflexion in pwMS computed using an objective and independent of human criterion method, as an electroencephalogram (EEG) based biomarker. EEG signals were recorded in eight persons with neither neurological condition nor motor dysfunction and eight pwMS with relapsing-remitting, primary progressive or secondary progressive MS. Recordings were divided into three groups: control, more affected lower limb and less affected lower limb. The ERD-onset latency was determined using a method based on the percent of ERD time course and the cluster depth tests. The median and interquartile range of the ERD-onset latency were 1186.0 (1100.0, 1250.0) ms; 1064.0 (1031.0, 1127.0) ms for the more and less affected groups respectively, whereas the median and interquartile range for the control group was 656.0 (472.2, 950.0) ms. There was a significant delay in the ERD-onset latencies of the pwMS groups compared to the control group (p<0.001 for both comparisons). These findings suggest that the ERD-onset latency computed using the proposed method could be used as an EEG biomarker to evaluate disease progression or therapeutic interventions in pwMS.