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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Jun 2, 2025

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
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MULTICENTRIC CASTLEMAN DISEASE PRESENTING WITH BILATERAL PANUVEITIS.

Afonso Murta1, Catarina Mota, Bruna Cunha

  • 1Unidade Local de Saúde São José, Lisbon, Portugal .

Retinal Cases & Brief Reports
|January 17, 2025
PubMed
Summary

This case report details a rare instance of Multicentric Castleman

Keywords:
Castleman diseasechoroidal foldsinflammationlymphoproliferativeuveitis

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Area of Science:

  • Ophthalmology and Hematology
  • Rare disease presentation and management

Background:

  • Multicentric Castleman's Disease (MCD) is a rare lymphoproliferative disorder with diverse systemic manifestations.
  • Ocular involvement in MCD is uncommon, making early diagnosis challenging.
  • Bilateral panuveitis can be a presenting symptom of underlying systemic conditions.

Purpose of the Study:

  • To document an unusual case of MCD presenting primarily with bilateral panuveitis.
  • To highlight the diagnostic pathway and successful management of this rare presentation.

Main Methods:

  • A case report detailing a 65-year-old male patient with progressive blurred vision.
  • Diagnostic workup included ophthalmological examination, CT scans, and lymph node biopsy.
  • Treatment involved topical and systemic corticosteroids, followed by siltuximab.

Main Results:

  • The patient presented with bilateral panuveitis, initially suspected as intraocular lymphoma.
  • Excisional biopsy confirmed plasmacytic type Multicentric Castleman's Disease.
  • Treatment with corticosteroids and siltuximab led to significant improvement in ocular and systemic symptoms.

Conclusions:

  • This is the first reported case of MCD diagnosed via investigation of bilateral panuveitis.
  • Successful management was achieved with a combination of corticosteroids and siltuximab.
  • Emphasizes the importance of considering systemic diseases in unexplained panuveitis.