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pDCs, type 1 IFN, and the female predileXion of SSc

Nikhil Jiwrajka1,2, Montserrat C Anguera1

  • 1Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.

The Journal of Experimental Medicine
|January 17, 2025
PubMed

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In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.  
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