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Updated: Jun 2, 2025

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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The FBXO45-GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis

Anagh A Sahasrabuddhe1,2, Xiaofei Chen3, Kaiyu Ma4

  • 1Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Cancer Discovery
|January 17, 2025
PubMed
Summary

Researchers identified a new ubiquitin ligase-substrate pathway (FBXO45-GEF-H1) crucial for germinal center formation and B-cell lymphoma development. This discovery offers new therapeutic targets for B-cell cancers.

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