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Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Functions of Thyroid Hormones01:18

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Major Hormones and Their Functions01:27

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Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
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Insufficient Sleep and Sleep Deprivation01:13

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Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
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Hormonal Regulation01:40

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Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
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Updated: Jun 2, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
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Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

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Shift work, thyroid function and liver function among subway workers.

F Yu1, J Liu2, T Qu1

  • 1Department of Occupational and Environmental Health, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China.

Occupational Medicine (Oxford, England)
|January 17, 2025
PubMed
Summary
This summary is machine-generated.

Shift work is linked to higher alkaline phosphatase (ALP) levels in subway workers. This effect is partly explained by changes in thyroid hormones, specifically total triiodothyronine (TT3) and free thyroxine (FT4).

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Area of Science:

  • Occupational Health
  • Endocrinology
  • Hepatology

Background:

  • Shift work is a known risk factor for liver injury.
  • The precise impact of shift work on liver function and the underlying mechanisms remain incompletely understood.

Purpose of the Study:

  • To examine the relationship between shift work and liver function parameters.
  • To investigate the potential mediating role of thyroid function indicators in this association.

Main Methods:

  • A cross-sectional study was conducted with 724 subway workers.
  • Multivariate linear regression and mediation analyses were employed to assess associations and mediating effects.

Main Results:

  • Shift work correlated with elevated alkaline phosphatase (ALP), total triiodothyronine (TT3), and free thyroxine (FT4) levels.
  • Thyroid hormones (TT3 and FT4) partially mediated the association between shift work and increased ALP levels, accounting for 39% and 29% respectively.
  • Associations were more pronounced in workers over 30 and among alcohol users for certain liver enzymes.

Conclusions:

  • Shift work is associated with increased ALP levels in subway workers.
  • Thyroid function indicators, specifically TT3 and FT4, play a partial mediating role in the link between shift work and elevated ALP.