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Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

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Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

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Endometrial scratching before euploid embryo transfer: a case-control study.

Sophia M K Lindekugel¹, Lexi Rose Frankel², Jeffrey L Deaton²

¹Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.

Journal of Assisted Reproduction and Genetics

|January 17, 2025

Summary

Endometrial scratching before frozen embryo transfer did not improve IVF success rates. However, it was associated with a higher risk of second-trimester loss and chronic endometritis.

Keywords:

Endometrial scratching Endometritis IVF-ET Miscarriage Pregnancy

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Area of Science:

Reproductive Endocrinology
In Vitro Fertilization
Gynecologic Surgery

Background:

Endometrial scratching is a minimally invasive procedure sometimes used to improve implantation rates.
Its efficacy in conjunction with preimplantation genetic testing for aneuploidy (PGT-A) and frozen embryo transfer (FET) remains under investigation.

Purpose of the Study:

To evaluate the impact of endometrial scratching on the success rates of in vitro fertilization (IVF) using frozen embryo transfer (FET) in women undergoing preimplantation genetic testing for aneuploidy (PGT-A).

Main Methods:

A retrospective study comparing women who underwent endometrial scratching (biopsy) at oocyte retrieval to a control group without scratching.
Key endpoints included pregnancy loss, clinical pregnancy rate (CPR), ongoing pregnancy rate (OPR), live birth rate, and incidence of chronic endometritis (CE).

Main Results:

No significant differences were observed in total pregnancy rates, CPR, or OPR between the scratching and control groups.
The incidence of chronic endometritis (CE) was 10.8% in the scratching group.
A significantly higher risk of second-trimester loss was noted in the group that underwent endometrial scratching.

Conclusions:

Endometrial scratching prior to frozen euploid embryo transfer did not enhance pregnancy outcomes.
The procedure was associated with an increased likelihood of second-trimester pregnancy loss.
Chronic endometritis (CE) was a common finding in patients who underwent endometrial scratching at the time of oocyte retrieval.