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Increasing skeletal involution in the elderly?

J D Ringe, W Rehpenning, E Steinhagen-Thiessen

    Mechanisms of Ageing and Development
    |January 1, 1985
    PubMed
    Summary
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    Bone mineral content (MC) in older adults shows distinct aging patterns. Females experience a slight increase in radius MC decrease, while males show accelerated MC loss after age 80.

    Area of Science:

    • Gerontology
    • Bone Physiology
    • Radiology

    Background:

    • Bone mineral content (MC) typically increases in adolescence, peaks between 30-40 years, and declines with age.
    • Post-peak MC decline is generally more pronounced in females than males.
    • Existing literature presents varied findings on MC changes during aging.

    Purpose of the Study:

    • To investigate age-related changes in bone mineral content (MC) in individuals over 70 years old.
    • To compare MC decline patterns in males and females in advanced age.
    • To examine MC changes at different sites of the radius.

    Main Methods:

    • Cross-sectional study involving 180 subjects aged over 70.
    • Measurement of radius bone mineral content (MC) at two sites: pure cortical (1/3-site) and mixed cancellous/compact (1/10-site).

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  • Analysis of annual decrease rates in MC for both sexes.

    • Main Results:

    • A slight increase in the annual decrease of radius MC was observed in females.
    • A distinct acceleration of MC decrease was noted in males after approximately 80 years of age.
    • These accelerated changes were consistent across both the 1/3-site and 1/10-site of the radius.

    Conclusions:

    • The study reveals specific patterns of bone mineral content (MC) decline in elderly populations, differing from general trends.
    • Accelerated bone loss in males over 80 warrants further investigation.
    • Findings suggest population-specific differences in age-related bone mineral changes.