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Intestinal Distension Induced by Luminal D-allulose Promotes GLP-1 Secretion in Male Rats.

Shiori Mizuma1, Masaki Hayakawa1, Tohru Hira1,2

  • 1Laboratory of Nutritional Biochemistry, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.

Endocrinology
|January 17, 2025
PubMed
Summary

D-allulose stimulates glucagon-like peptide-1 (GLP-1) secretion by causing intestinal distension. This physical mechanism, rather than metabolism, is a key driver for GLP-1 release, offering new insights into its regulation.

Keywords:
D-alluloseglucagon-like peptide-1intestinal distension

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