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Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
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Strain-promoted azide-alkyne cycloaddition enhanced by secondary interactions

Riko Yoshikawa1, Shohei Hamada1, Jun-Ichi Matsuo1

  • 1Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. jimatsuo@p.kanazawa-u.ac.jp.

Organic & Biomolecular Chemistry
|January 17, 2025
PubMed
Summary

This study shows that secondary interactions accelerate azide-alkyne cycloaddition reactions. These interactions also control regioselectivity, leading to triazole formation with boronate ester groups.

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