Superior hypophyseal artery aneurysm: microsurgical vs. endovascular treatment

This study aimed to provide an updated evidence of superior hypophyseal artery (SHA) aneurysms management, including their clinical implications, predictive factors for rupture, therapeutic approaches, and post-treatment outcomes. This systematic review and meta-analysis, following PRISMA guidelines, assessed the literature on superior hypophyseal artery aneurysms. Studies were selected based on predefined criteria, focusing on coiling and clipping interventions. Data were extracted and analyzed using SPSS and Cochrane RevMan, with assessments of heterogeneity, sensitivity, and publication bias. Study quality was evaluated using the Newcastle-Ottawa Scale and RoB2. A total of 20 studies involving 316 patients were included. The clipping group had a mean age of 53.8 years, while the coiling group had 50.3 years. Most aneurysms were smaller than 7 mm. Aneurysm remnants occurred in 1.1% after clipping and 2.8% after coiling. Clipping was associated with lower recurrence rates (0% vs. 9.3%) and fewer visual disturbances and vasospasms. Mortality was equal (1%) for both groups. The coiling group had better outcomes on the modified Rankin Scale (94% vs. 73% for clipping). Meta-analysis confirmed that clipping had better recurrence and functional outcomes, with no significant differences in aneurysm size or mortality. Surgical clipping is a viable treatment for SHA aneurysms but carries risks, while coil embolization offers a safer, effective alternative. Early intervention, especially for larger aneurysms (> 7 mm), is crucial to prevent rupture. Future research should focus on personalized treatment strategies, as this study's small sample size and study limitations warrant further investigation.