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Published on: February 8, 2020
[Histomorphologically defined renal cell carcinomas 2025 : Current WHO classification and emerging future subtypes]
C Stöhr1,2,3, A Fiegl1,2,3, C Bercebal1,2,3
1Institut für Pathologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Krankenhausstraße 8-10, 91054, Erlangen, Deutschland.
Background:
The latest edition of the WHO classification of urinary and male genital tumours was published in 2022. The revision was based on the newest scientific literature. This article summarizes the updated recommendations regarding the classification of histomorphologically defined tumours.
Results And Conclusions:
The current edition of the WHO classification made some adjustments on the classification of histomorphologically defined tumour types. Papillary renal cell carcinoma is no longer categorized into two subtypes. Also, the new classification recognized the benign nature of clear cell papillary tumours, which are no longer regarded as carcinomas. Finally, several emerging renal tumours were introduced.
Insights
The 2022 WHO classification updates urinary and male genital tumor diagnoses. Key changes include revised papillary renal cell carcinoma subtypes and recognizing clear cell papillary tumors as benign.
Area of Science:
- Uropathology
- Oncology
- Histopathology
Context:
- The World Health Organization (WHO) released the 2022 classification of urinary and male genital tumors, incorporating recent scientific advancements.
- This classification is crucial for standardizing tumor diagnosis and treatment globally.
Purpose:
- To summarize the key updates and revised recommendations for histomorphologically defined tumors in the 2022 WHO classification.
- To highlight significant changes in the categorization of specific tumor types, particularly renal cell carcinomas.
Summary:
- The 2022 WHO classification has revised the categorization of papillary renal cell carcinoma, moving away from previous subtype classifications.
- Clear cell papillary tumors are now recognized as benign, no longer classified as carcinomas.
- Several novel renal tumors have been introduced in the latest edition.
Impact:
- These updates facilitate more accurate diagnoses and consistent reporting of urinary and male genital tumors.
- The revised classification aids in clinical decision-making and prognostic assessments.
- Standardized classification promotes better understanding and research in uropathology and oncology.
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