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Prevalence and Risk Factors of Acute Kidney Injury After Colorectal Cancer Surgery

  • 0Nephrology and Dialysis Unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Journal of Gastrointestinal Cancer +

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January 17, 2025

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January 17, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Acute kidney injury (AKI) affects over 25% of colorectal cancer patients post-surgery or chemotherapy. Pre-existing chronic kidney disease and neoadjuvant therapy are key risk factors, significantly worsening patient survival.

Area Of Science

  • Nephrology
  • Oncology
  • Surgical Outcomes

Background

  • Acute kidney injury (AKI) is a critical complication in colorectal cancer (CRC) patients, impacting outcomes after surgery and chemotherapy.
  • Understanding AKI's prevalence and risk factors is crucial for improving patient management and survival rates.

Purpose Of The Study

  • To determine the incidence, risk factors, and survival impact of postoperative AKI (PO-AKI) and post-chemotherapy AKI (PC-AKI) in Egyptian CRC patients.

Main Methods

  • Retrospective analysis of 561 CRC patients' data over 5 years.
  • Calculation of PO-AKI and PC-AKI incidence.
  • Univariate and multivariate analyses to identify AKI predictors.
  • Survival analysis using survival curves.

Main Results

  • PO-AKI incidence was 10.5%; significant predictors included neoadjuvant therapy and chronic kidney disease (CKD).
  • PC-AKI incidence was 18.7%; significant predictors were CKD and Irinotecan-based chemotherapy.
  • Overall survival was significantly reduced in patients who developed PO-AKI or PC-AKI (p < 0.001).

Conclusions

  • AKI affects over 25% of CRC patients, with CKD and specific treatments being major risk factors.
  • Modifiable risks include hypoalbuminemia and intraoperative hypotension; non-modifiable risks include CKD, neoadjuvant therapy, and Irinotecan regimens.
  • Even mild AKI (Stage I) is linked to poorer overall survival in CRC patients.

Keywords:

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