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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
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Metabolic reprogramming and signaling adaptations in anoikis resistance: mechanisms and therapeutic targets

Chao He1, Jie He2

  • 1Department of Surgical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Molecular and Cellular Biochemistry
|January 17, 2025
PubMed

Insights

Cancer cells evade anoikis, a cell death process, enabling metastasis. This review details mechanisms like epithelial-mesenchymal transition and metabolic changes, highlighting therapeutic targets to inhibit cancer spread.

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Biology

Background:

  • Anoikis, programmed cell death upon extracellular matrix detachment, maintains tissue homeostasis.
  • Cancer cells acquire anoikis resistance to survive detachment and promote distant metastasis.
  • Altered protein expression in suspended cancer cells indicates significant metabolic and signaling pathway changes.

Purpose of the Study:

  • To review the regulatory mechanisms driving anoikis resistance in cancer cells.
  • To explore the roles of epithelial-mesenchymal transition, cancer stem cells, metabolic reprogramming, and signaling pathways.
  • To identify potential therapeutic targets, including reagents and non-coding RNAs, for inhibiting cancer progression and metastasis.

Main Methods:

  • Review of existing literature on anoikis resistance in cancer.
  • Analysis of differentially expressed proteins in suspended versus adherent cancer cells.
  • Identification of key regulatory pathways and potential therapeutic interventions.

Main Results:

  • Epithelial-mesenchymal transition, cancer stem cell traits, metabolic reprogramming, and signaling pathway alterations are key to anoikis resistance.
  • Specific reagents and non-coding RNAs targeting these pathways show potential for therapeutic application.
  • Understanding these mechanisms is crucial for developing strategies against tumor progression and metastasis.

Conclusions:

  • Anoikis evasion is a critical step in cancer metastasis.
  • Targeting pathways involved in anoikis resistance offers promising therapeutic strategies.
  • Further research into these mechanisms can lead to novel treatments for inhibiting cancer spread.
Keywords:
Anoikis resistanceCancer metastasisMetabolic reprogrammingTherapeutic strategy

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