Related Experiment Video

Updated: Jun 1, 2025

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
09:52

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia

Published on: December 4, 2018

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Nuclear Factor of Activated T Cells (NFAT) Proteins as Targeted Molecules in Diseases: A Narrative Review

Mohadese Mozafari1, Siti Nurnasihah Md Hashim1, Khairul Bariah Ahmad Amin Noordin1

  • 1Basic and Medical Sciences Unit, School of Dental Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, MYS.

Cureus
|January 17, 2025
PubMed

Insights

The nuclear factor of activated T cells (NFAT) pathway regulates cellular processes and is linked to diseases like cancer. This review updates understanding of NFAT proteins and their signaling for potential therapeutic strategies.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cellular Biology

Background:

  • The nuclear factor of activated T cells (NFAT) pathway is crucial for physiological and pathological cellular regulation.
  • NFAT signaling is implicated in diseases, including cancer progression and angiogenesis.
  • Limited comprehensive information exists on NFAT proteins and their signaling pathways compared to other established pathways.

Purpose of the Study:

  • To provide an updated understanding of the five NFAT proteins and their signaling mechanisms.
  • To analyze recent studies on the NFAT pathway and its role in disease.
  • To explore the potential for developing therapeutic strategies targeting NFAT.

Main Methods:

  • Literature review of recent studies on NFAT proteins and signaling.
  • Analysis of NFAT pathway involvement in physiological and pathological processes.
  • Synthesis of current knowledge on NFAT's role in disease development.

Main Results:

  • NFAT proteins play significant roles in various cellular functions.
  • NFAT signaling is a key contributor to disease pathogenesis, particularly in cancer and angiogenesis.
  • Recent research has provided new insights into NFAT protein functions and interactions.

Conclusions:

  • Enhanced understanding of NFAT proteins and their signaling pathways is crucial.
  • NFAT's role in disease offers potential for novel therapeutic interventions.
  • Further research into NFAT signaling could lead to targeted treatments for various conditions.
Keywords:
angiogenesiscancerendothelial cellnfat pathwaynfat proteinsstem cell

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