Clinical Presentation and Percutaneous Treatment of Hemolytic Anemia Associated With Paravalvular Leak After TAVR

Paravalvular leak (PVL) following transcatheter aortic valve replacement (TAVR) is an established complication, albeit rarely associated with hemolytic anemia. This report details 3 cases of significant hemolytic anemia attributed to TAVR-induced PVL, each with distinct clinical presentations and manifestations. These cases underscore the diverse and occasionally subtle clinical presentation of aortic PVL-associated hemolytic anemia. We explore the technical nuances and challenges of percutaneous PVL closure and emphasize the successful resolution of hemolytic anemia by using percutaneous PVL plugging with occluder devices. Through this case series, we encourage the awareness of PVL-associated hemolytic anemia in the differential diagnosis of patients presenting with new onset anemia after TAVR and demonstrate the efficacy of percutaneous closure techniques in resolving this serious condition.