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Published on: December 10, 2013
Predictive value of plasma sB7-H3 and YKL-40 in pediatric refractory Mycoplasma pneumoniae pneumonia
QiuMin Zhao1, ShiYan Ji2, HaiPing Jiang1
1Department of Laboratory Medicine, Changzhou Children's Hospital of Nantong University, Changzhou, Jiangsu, 213003, China.
Objective:
This study investigated the clinical significance of plasma sB7-H3 and YKL-40 levels in children with refractory Mycoplasma pneumoniae pneumonia (RMPP).
Methods:
A total of 182 RMPP patients (103 general Mycoplasma pneumoniae patients and 79 RMPP patients) were included. sB7-H3, YKL-40, and other inflammatory factors were measured. Independent factors associated with the early diagnosis of RMPP were determined. The value of each independent risk factor in predicting RMPP was evaluated.
Results:
The RMPP group reported significantly longer hospital stays and total fever durations. Levels of C-reactive protein, D-dimer, IL-13, IL-6/-10, sB7-H3, and YKL-40 were higher in the RMPP group. sB7-H3 was positively correlated with IL-13, IL-6, and IL-4, whereas YKL-40 was positively correlated with all of the above indicators (IL-5 was also included). sB7-H3 and YKL-40 were independent risk factors for RMPP. The critical values for sB7-H3 and YKL-40 were 3.525 and 313.3 ng/mL, respectively. sB7-H3 and YKL-40 had areas under the curve of 0.734 and 0.859, respectively. YKL-40 had high sensitivity and specificity of 88.61 and 87.38%, respectively. Both indicators had predictive value, YKL-40 had the highest predictive ability for RMPP.
Conclusion:
Detection of sB7-H3 and YKL-40 levels in the plasma may be useful in diagnosing RMPP early in the disease process.
Insights
Plasma levels of sB7-H3 and YKL-40 show promise for early diagnosis of refractory Mycoplasma pneumoniae pneumonia (RMPP) in children. YKL-40 demonstrated the highest predictive ability for RMPP.
Area of Science:
- Pediatric Infectious Diseases
- Clinical Biomarkers
- Respiratory Medicine
Background:
- Refractory Mycoplasma pneumoniae pneumonia (RMPP) presents clinical challenges in pediatric patients.
- Identifying reliable biomarkers for early RMPP diagnosis is crucial for timely intervention.
Purpose of the Study:
- To investigate the clinical significance of plasma soluble B7-H3 (sB7-H3) and YKL-40 levels in children with RMPP.
- To evaluate the diagnostic and predictive value of sB7-H3 and YKL-40 for RMPP.
Main Methods:
- A cohort of 182 children, including 79 with RMPP, were analyzed.
- Plasma levels of sB7-H3, YKL-40, and inflammatory markers were measured.
- Statistical analyses identified independent risk factors and assessed predictive values for RMPP.
Main Results:
- RMPP patients exhibited elevated sB7-H3 and YKL-40 levels compared to general pneumonia cases.
- Both sB7-H3 and YKL-40 were identified as independent risk factors for RMPP.
- YKL-40 demonstrated high sensitivity (88.61%) and specificity (87.38%), with the highest predictive ability for RMPP.
Conclusions:
- Plasma sB7-H3 and YKL-40 levels are significantly elevated in children with RMPP.
- These biomarkers hold potential for early and accurate diagnosis of RMPP in pediatric populations.
- YKL-40 shows particular promise as a sensitive and specific indicator for RMPP.
