Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Robust optimization of a novel ultraviolet (UV) photoreactor for water disinfection: A neural network approach.

Chemosphere·2024
Same author

Viscoelastic Effects on Spontaneous Imbibition in Unsaturated Porous Membranes of Complex Shapes.

Langmuir : the ACS journal of surfaces and colloids·2024
Same author

Development and modeling of a novel type of photoreactors with exterior ultraviolet (UV) reflector for water treatment applications.

Scientific reports·2023
Same author

Stochastic simulation of the FDA centrifugal blood pump benchmark.

Biomechanics and modeling in mechanobiology·2021
Same author

Numerical simulation of dissolved air flotation using a lattice Boltzmann method.

Physical review. E·2020
Same author

Nondeterministic computational fluid dynamics modeling of Escherichia coli inactivation by peracetic acid in municipal wastewater contact tanks.

Environmental science & technology·2015

Related Experiment Video

Updated: Jun 1, 2025

Analyzing Mixing Inhomogeneity in a Microfluidic Device by Microscale Schlieren Technique
10:12

Analyzing Mixing Inhomogeneity in a Microfluidic Device by Microscale Schlieren Technique

Published on: June 12, 2015

8.9K

Investigating Cell-Induced Mixing Dynamics in Microfluidic Droplets Using the Lattice Boltzmann Method.

Kamal Jannati1, Mohammad-Hassan Rahimian2, Mehrdad Raisee3

  • 1CNNFM Lab, School of Mechanical Engineering, College of Engineering, University of Tehran, P.O. Box 11155-4563 Tehran, Iran.

Langmuir : the ACS Journal of Surfaces and Colloids
|January 17, 2025
PubMed
Summary
This summary is machine-generated.

Cell deformability significantly impacts mixing efficiency in microfluidic droplets. Moderate cell deformability enhances mixing by inducing flow asymmetry, crucial for applications in diagnostics and synthesis.

More Related Videos

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
08:20

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

10.3K
Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow
09:45

Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow

Published on: February 4, 2011

27.4K

Related Experiment Videos

Last Updated: Jun 1, 2025

Analyzing Mixing Inhomogeneity in a Microfluidic Device by Microscale Schlieren Technique
10:12

Analyzing Mixing Inhomogeneity in a Microfluidic Device by Microscale Schlieren Technique

Published on: June 12, 2015

8.9K
Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
08:20

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

10.3K
Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow
09:45

Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow

Published on: February 4, 2011

27.4K

Area of Science:

  • Fluid dynamics
  • Biophysics
  • Microfluidics

Background:

  • Microfluidic devices offer precise control over fluid behavior.
  • Efficient mixing is critical for various applications, including chemical synthesis and biomedical diagnostics.
  • Understanding cell dynamics within droplets is key to optimizing microfluidic processes.

Purpose of the Study:

  • To investigate how cell dynamics, including motion and deformability, affect mixing efficiency in microfluidic droplets.
  • To quantify the relationship between cell-induced flow asymmetry and mixing enhancement.
  • To identify optimal cell properties for maximizing mixing in microfluidic systems.

Main Methods:

  • Numerical simulations of droplets containing encapsulated cells.
  • Varying Peclet numbers (Pe = 100-800) and coupling constants (k = 0.0025, 0.005, 0.0075).
  • Analysis of velocity and concentration fields using mixing and asymmetry indices.

Main Results:

  • Encapsulated cells significantly enhance mixing, especially at high Peclet numbers.
  • Cell-induced disturbances in velocity fields disrupt symmetrical flow, improving mixing.
  • Moderate cell deformability leads to increased off-center movement, chaotic flow, and enhanced mixing.

Conclusions:

  • Optimal microfluidic droplet mixing is achieved with moderately deformable cells.
  • Cell deformability influences flow field asymmetry and convective transport.
  • Findings provide insights for designing microfluidic systems for precise mixing control.