Effects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Dichlorvos (DDVP) pesticide exposure damages the liver by impairing autophagy and increasing oxidative stress. Targeting IRGM protein may offer a new therapeutic strategy for DDVP-induced liver injury.
Area Of Science
- Toxicology
- Hepatology
- Molecular Biology
Background
- Dichlorvos (DDVP), an organophosphorus pesticide, is widely used in agriculture.
- Epidemiological studies link DDVP exposure to increased liver disease incidence.
- Mechanisms of DDVP-induced hepatotoxicity and regulatory pathways are not fully understood.
Purpose Of The Study
- To investigate the in vivo and in vitro effects of DDVP on liver damage.
- To elucidate the molecular mechanisms underlying DDVP-induced liver injury.
- To explore potential therapeutic targets for DDVP hepatotoxicity.
Main Methods
- Utilized Wistar rats and BRL-3A cells for in vivo and in vitro models.
- Assessed hepatocyte autophagy, reactive oxygen species (ROS) activity, RNA sequencing, and metabolomic analyses.
- Employed adeno-associated virus (AAV) for hepatic portal vein injection to target IRGM overexpression.
Main Results
- DDVP exposure was found to impair hepatocyte autophagy and increase ROS activity.
- RNA sequencing and metabolomic analyses identified affected pathways including ABC transporters and amino acid biosynthesis.
- Targeting IRGM overexpression via AAV injection significantly mitigated DDVP-induced liver injury in rats.
Conclusions
- DDVP induces liver damage through ROS- and autophagy-dependent mechanisms, partly by downregulating IRGM.
- IRGM plays a crucial role in the molecular mechanisms of DDVP-induced liver injury.
- IRGM represents a potential novel therapeutic target for organophosphate poisoning and DDVP-induced liver damage.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...